275 research outputs found
Robustness of adiabatic quantum computation
We study the fault tolerance of quantum computation by adiabatic evolution, a
quantum algorithm for solving various combinatorial search problems. We
describe an inherent robustness of adiabatic computation against two kinds of
errors, unitary control errors and decoherence, and we study this robustness
using numerical simulations of the algorithm.Comment: 11 pages, 5 figures, REVTe
Depression, ART Adherence, and Receipt of Case Management Services by Adults with HIV in North Carolina, Medical Monitoring Project, 2009–2013
Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009–2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with “probable current depression” and with 100% ART dose adherence. After weighting, 53.2% of patients reported receiving case management, 21.7% reported depression, and 87.0% reported ART adherence. Depression prevalence was higher among those reporting case management (24.9%) than among other patients (17.6%) (p < 0.01). Case management was associated with depression among patients living above the poverty level [adjusted prevalence ratio (aPR), 2.05; 95% confidence interval (CI) 1.25–3.36], and not among other patients (aPR, 1.01; 95% CI 0.72–1.43). Receipt of case management was not associated with ART adherence (aPR, 1.00; 95% CI 0.95–1.05). Our analysis indicates a need for more effective depression treatment, even among persons receiving case management services. Self-reported ART adherence was high overall, though lower among persons experiencing depression (unadjusted prevalence ratio, 0.92; 95% CI 0.86–0.99). Optimal HIV clinical and prevention outcomes require addressing psychological wellbeing, monitoring of ART adherence, and effective case management services
Topological quantum memory
We analyze surface codes, the topological quantum error-correcting codes
introduced by Kitaev. In these codes, qubits are arranged in a two-dimensional
array on a surface of nontrivial topology, and encoded quantum operations are
associated with nontrivial homology cycles of the surface. We formulate
protocols for error recovery, and study the efficacy of these protocols. An
order-disorder phase transition occurs in this system at a nonzero critical
value of the error rate; if the error rate is below the critical value (the
accuracy threshold), encoded information can be protected arbitrarily well in
the limit of a large code block. This phase transition can be accurately
modeled by a three-dimensional Z_2 lattice gauge theory with quenched disorder.
We estimate the accuracy threshold, assuming that all quantum gates are local,
that qubits can be measured rapidly, and that polynomial-size classical
computations can be executed instantaneously. We also devise a robust recovery
procedure that does not require measurement or fast classical processing;
however for this procedure the quantum gates are local only if the qubits are
arranged in four or more spatial dimensions. We discuss procedures for
encoding, measurement, and performing fault-tolerant universal quantum
computation with surface codes, and argue that these codes provide a promising
framework for quantum computing architectures.Comment: 39 pages, 21 figures, REVTe
Impact of culture towards disaster risk reduction
Number of natural disasters has risen sharply worldwide making the risk of disasters a global concern. These disasters have created significant losses and damages to humans, economy and society. Despite the losses and damages created by disasters, some individuals and communities do not attached much significance to natural disasters. Risk perception towards a disaster not only depends on the danger it could create but also the behaviour of the communities and individuals that is governed by their culture. Within this context, this study examines the relationship between culture and disaster risk reduction (DRR). A comprehensive literature review is used for the study to evaluate culture, its components and to analyse a series of case studies related to disaster risk.
It was evident from the study that in some situations, culture has become a factor for the survival of the communities from disasters where as in some situations culture has acted as a barrier for effective DRR activities. The study suggests community based DRR activities as a mechanism to integrate with culture to effectively manage disaster risk
Change in glomerular filtration rate over time in the Oxford Renal Cohort Study:observational study
Background: Decline in kidney function can result in adverse health outcomes. The Oxford Renal Cohort Study has detailed baseline assessments from 884 participants ≥60 years of age. Aim: To determine the proportion of participants with a decline in estimated glomerular filtration rate (eGFR), identify determinants of decline, and determine proportions with chronic kidney disease (CKD) remission. Design and setting: Observational cohort study in UK primary care. Method: Data were used from baseline and annual follow-up assessments to monitor change in kidney function. Rapid eGFR decline was defined as eGFR decrease >5 ml/min/1.73 m2/year, improvement as eGFR increase >5 ml/min/1.73 m2/year, and remission in those with CKD at baseline and eGFR >60 ml/min/1.73 m2 during follow-up. Cox proportional hazard models were used to identify factors associated with eGFR decline. Results: There was a net decline in eGFR in the 884 participants over 5 years of follow-up. In 686 participants with >2 eGFR tests with a median follow-up of 2.1 years, 164 (24%) evidenced rapid GFR decline, 185 (27%) experienced eGFR improvement, and 82 of 394 (21%) meeting CKD stage 1-4 at baseline experienced remission. In the multivariable analysis, smoking status, higher systolic blood pressure, and being known to have CKD at cohort entry were associated with rapid GFR decline. Those with CKD stage 3 at baseline were less likely to exhibit GFR decline compared with normal kidney function. Conclusion: This study established that 24% of people evidenced rapid GFR decline whereas 21% evidenced remission of CKD. People at risk of rapid GFR decline may benefit from closer monitoring and appropriate treatment to minimise risks of adverse outcomes, although only a small proportion meet the National Institute for Health and Care Excellence criteria for referral to secondary care.</p
Scalar Bilepton Dark Matter
In this work we show that 3-3-1 model with right-handed neutrinos has a
natural weakly interacting massive particle (WIMP) dark mater candidate. It is
a complex scalar with mass of order of some hundreds of GeV which carries two
units of lepton number, a scalar bilepton. This makes it a very peculiar WIMP,
very distinct from Supersymmetric or Extra-dimension candidates. Besides,
although we have to make some reasonable assumptions concerning the several
parameters in the model, no fine tunning is required in order to get the
correct dark matter abundance. We also analyze the prospects for WIMP direct
detection by considering recent and projected sensitivities for WIMP-nucleon
elastic cross section from CDMS and XENON Collaborations.Comment: 21 pages, 8 figures, uses iopart.cls, same text as published version
with a small different arrangement of figure
Analysis of the low-energy electron-recoil spectrum of the CDMS experiment
We report on the analysis of the low-energy electron-recoil spectrum from the
CDMS II experiment using data with an exposure of 443.2 kg-days. The analysis
provides details on the observed counting rate and possible background sources
in the energy range of 2 - 8.5 keV. We find no significant excess in the
counting rate above background, and compare this observation to the recent DAMA
results. In the framework of a conversion of a dark matter particle into
electromagnetic energy, our 90% confidence level upper limit of 0.246
events/kg/day at 3.15 keV is lower than the total rate above background
observed by DAMA by 8.9. In absence of any specific particle physics
model to provide the scaling in cross section between NaI and Ge, we assume a
Z^2 scaling. With this assumption the observed rate in DAMA differs from the
upper limit in CDMS by 6.8. Under the conservative assumption that the
modulation amplitude is 6% of the total rate we obtain upper limits on the
modulation amplitude a factor of ~2 less than observed by DAMA, constraining
some possible interpretations of this modulation.Comment: 4 pages, 3 figure
Exclusion Limits on the WIMP-Nucleon Cross-Section from the First Run of the Cryogenic Dark Matter Search in the Soudan Underground Lab
The Cryogenic Dark Matter Search (CDMS-II) employs low-temperature Ge and Si
detectors to seek Weakly Interacting Massive Particles (WIMPs) via their
elastic scattering interactions with nuclei. Simultaneous measurements of both
ionization and phonon energy provide discrimination against interactions of
background particles. For recoil energies above 10 keV, events due to
background photons are rejected with >99.99% efficiency. Electromagnetic events
very near the detector surface can mimic nuclear recoils because of reduced
charge collection, but these surface events are rejected with >96% efficiency
by using additional information from the phonon pulse shape. Efficient use of
active and passive shielding, combined with the the 2090 m.w.e. overburden at
the experimental site in the Soudan mine, makes the background from neutrons
negligible for this first exposure. All cuts are determined in a blind manner
from in situ calibrations with external radioactive sources without any prior
knowledge of the event distribution in the signal region. Resulting
efficiencies are known to ~10%. A single event with a recoil of 64 keV passes
all of the cuts and is consistent with the expected misidentification rate of
surface-electron recoils. Under the assumptions for a standard dark matter
halo, these data exclude previously unexplored parameter space for both
spin-independent and spin-dependent WIMP-nucleon elastic scattering. The
resulting limit on the spin-independent WIMP-nucleon elastic-scattering
cross-section has a minimum of 4x10^-43 cm^2 at a WIMP mass of 60 GeV/c^2. The
minimum of the limit for the spin-dependent WIMP-neutron elastic-scattering
cross-section is 2x10^-37 cm^2 at a WIMP mass of 50 GeV/c^2.Comment: 37 pages, 42 figure
Low-threshold analysis of CDMS shallow-site data
Data taken during the final shallow-site run of the first tower of the
Cryogenic Dark Matter Search (CDMS II) detectors have been reanalyzed with
improved sensitivity to small energy depositions. Four ~224 g germanium and two
~105 g silicon detectors were operated at the Stanford Underground Facility
(SUF) between December 2001 and June 2002, yielding 118 live days of raw
exposure. Three of the germanium and both silicon detectors were analyzed with
a new low-threshold technique, making it possible to lower the germanium and
silicon analysis thresholds down to the actual trigger thresholds of ~1 keV and
~2 keV, respectively. Limits on the spin-independent cross section for weakly
interacting massive particles (WIMPs) to elastically scatter from nuclei based
on these data exclude interesting parameter space for WIMPs with masses below 9
GeV/c^2. Under standard halo assumptions, these data partially exclude
parameter space favored by interpretations of the DAMA/LIBRA and CoGeNT
experiments' data as WIMP signals, and exclude new parameter space for WIMP
masses between 3 GeV/c^2 and 4 GeV/c^2.Comment: 18 pages, 12 figures, 5 table
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